Research Group
Cell and Developmental Biology
We research how cells become specialised, communicate with each other and respond to the environment, leading to an impact on the development of cancer, neurological diseases and the function of the immune system.
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Our research provides a natural training environment for the next generation of scientists by combining molecular, biochemical, gene editing and imaging approaches with structural biology. This enables advanced investigations into the complex mechanisms of fundamental biology.
We pursue a range of interests including:
- the molecular organisation of proteins and nucleic acids
- cell signalling pathways controlling gene expression, autophagy and cell growth
- mechanisms of chromosome segregation
- the structure and function of the immune system, plant growth and environmental interactions
- membrane proteins and cellular function
Our research provides experimental platforms to collaborate with other researchers in other areas. For instance, we work with our colleagues in medicine to exploit structural and functional studies on how cancer cells evade the immune system.
Supercharging your immune system
Research led by Professor Nullin Divecha and his laboratory team has identified a way to boost the power of the human immune system to find and destroy cancer cells within the body.
People, projects and publications
People
Research projects
Research project
IfLS Pilot Project: Multiplex in situ imaging and deep learning to investigate the contribution of abnormal cell divisions to breast tumour heterogeneity
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Investigating the role of oriented cell divisions in mammary epithelial morphogenesis and homeostasis using human organoids
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MRF Skills Training And Development Award
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Preclinical evaluation of potential therapeutic targets (Project 2)
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Role of autophagy in oncogenic RAS-induced invasive behaviour
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The Genetics and Developmental Biology of Cell Division in Mammary Stem Cells
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The Gerald Kerkut Charitable Trust PhD Studentship: The genetics and developmental biology of cell division in mammary stem cells
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The interactome of TRPA1 in Idiopathic Pulmonary Fibrotic Lung Fibroblasts
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The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)
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TURKISH EMBASSY Education Counsellor’s Office-PhD studentship
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Publications
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I am a T cell immunologist. I am interested in how early innate immune responses - particularly neutrophil infiltration and antimicrobial peptide production - affect T cell differentiation and function.