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Research Fellow in Bioinformatics/Epigenetics within the Faculty of Medicine at the ¾ÅÉ«ÊÓƵ
Research
Research groups
Research interests
- My current research mainly involves working with DNA methylation data to identify epigenetic marks for periconceptional paternal smoking exposure across generations. This Epigenome Wide Association Study is part of the Rhinessa multicentre population project. My expertise includes integrating multi-omic data such as SNP, transcriptome, methylation and interactome (PPI) at the system level to understand the molecular mechanisms underlying the origins of complex diseases. In my former position, I worked on the epigenetic effects of Maternal Gestation Diabetes (GDM) using the UPBEAT Offspring data supported by Diabetes UK.
Research projects
Publications
19 publications
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Biography
Dr Negusse graduated from Addis Ababa University with a BSc in Biological Science and an MSc in Biodiversity. He completed his MSc in Bioinformatics at Cardiff University. He undertook research into gene regulation, pathway analysis and protein structure prediction to support drug discovery at the University of South Wales, graduating with a PhD in Computational Biology in 2015.
Dr Negusse has a keen interest in understanding how genetics and environmental interactions affect gene function and disease outcomes. He joined the ¾ÅÉ«ÊÓƵ, Faculty of Biological Science in 2017 where he investigated the effect of maternal gestational diabetes on the offspring epigenome. His current work in the Faculty of Medicine involves studying the transgenerational effect of paternal smoking.
Qualifications
PhD, Computational Biology, University of South Wales 2015
MSc, Bioinformatics, Cardiff University 2010
MSc, Biodiversity, Addis Ababa University 2006
BSc, Biological Science, Addis Ababa University 1999
Appointments held
Research Fellow in Bioinformatics/ Epigenetics: Rhinessa EWAS Project at Faculty of Medicine, ¾ÅÉ«ÊÓƵ (2020 -present)
Research Fellow in Epigenetics: UPBEAT Diabetes UK project at Faculty of Biological Science, ¾ÅÉ«ÊÓƵ (2017 to 2020)
Bioinformatics Scientist II PhoreMost Ltd, Cambridge (2017)
Prizes
- Fathers’ preconception smoking and offspring DNA methylation (2024)
- Transcriptomic Analysis of SARS-CoV-2 severity in a South African Cohort (2025)