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Biological Sciences
Phone:
(023) 8059 0000
Email:
A.G.Lee@soton.ac.uk

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Emeritus Professor of Biochemistry

Professor Anthony Lee's photo

Professor Anthony Lee is Emeritus Professor of Biochemistry within Biological Sciences at the ¾ÅÉ«ÊÓƵ.

Career history

Emeritus Professor of Biochemistry, ¾ÅÉ«ÊÓƵ, UK.
Professor of Biochemistry, ¾ÅÉ«ÊÓƵ, UK.
National Institute for Medical Research, London, UK.
Research Fellow. King's College, Cambridge, UK.
Research Fellow. The Salters Company, London, UK.

Academic qualifications

Phd Chemistry. King's College, Cambridge, UK.
MA Chemistry. King's College, Cambridge, UK.

Research interests

The research of my group is focused on the structure and function of biological membranes. We are using a variety of biophysical (fluorescence spectroscopy, computer simulations), biochemical (protein purification, protein labelling, kinetics, cell biology), molecular biological (cloning and mutagenesis), and chemical (peptide and lipid synthesis) methods to answer the following questions:

  • How do lipids and proteins interact in a membrane?
  • How do lipids affect the activity of the Ca-ATPase of skeletal muscle sarcoplasmic reticulum?
  • How do lipids affect the function of channels such as the KcsA potassium channel and the mechanosensitive channel MscL?
  • How do lipids affect the function of membrane-bound enzymes such as the bacterial diacylglycerol kinase?
  • How do simple transmembrane a-helices as found in the Ca-ATPase, diacylglycerol kinase and KcsA interact with lipid bilayers?
  • How do proteins interact in a lipid bilayer?
  • How do phospholamban and sarcolipin interact with the Ca-ATPase and control its activity?
  • How do simple transmembrane a-helices interact and form helical bundles in a membrane?
  • How do transport proteins such as the Ca-ATPase transport ions across the membrane?
  • How is the hydrolysis of ATP coupled to movement of Ca?
  • How are membrane proteins targeted to the correct membrane in a cell?

Research group

Molecular and Cellular Biosciences

Professor Anthony Lee
Biological Sciences Faculty of Natural & Environmental Sciences Life Sciences Building 85 ¾ÅÉ«ÊÓƵ Highfield Campus ¾ÅÉ«ÊÓƵ SO17 1BJ

Room Number : 85/3041

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